Linked Life Data

2891584

Source:http://linkedlifedata.com/resource/pubmed/id/2891584

Statements in which the resource exists.
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pubmed-article:2891584pubmed:abstractTextThe present study was designed to determine whether somatostatin secretion induced by histamine or pentagastrin in the isolated luminally perfused mouse stomach was a direct effect of the secretagogues on gastric somatostatin cells or an indirect effect mediated by the increase in luminal acidity. Perfusion of the lumen with exogenous acid (80-480 nmol/min) caused an increase in somatostatin secretion in proportion to the increase in luminal acidity. The increase in somatostatin secretion was resistant to tetrodotoxin and attained maximal levels (61.6% +/- 8.7% above basal level) similar to those elicited by maximal doses of secretagogues. Conversely, neutralization of basal acid secretion with bicarbonate (20-160 nmol/min) caused a decrease in somatostatin secretion in proportion to the decrease in luminal acidity. Similarly, neutralization of the secretagogue-induced increments in acid secretion with bicarbonate or inhibition of the increments with cimetidine abolished the corresponding increments in somatostatin secretion. It is proposed that acid-induced release of somatostatin in proximity to parietal cells serves as a negative feedback mechanism restraining acid secretion.lld:pubmed
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pubmed-article:2891584pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:2891584pubmed:articleTitleRegulation of gastric somatostatin secretion in the mouse by luminal acidity: a local feedback mechanism.lld:pubmed
pubmed-article:2891584pubmed:affiliationDepartment of Medicine, Medical College of Virginia, Richmond.lld:pubmed
pubmed-article:2891584pubmed:publicationTypeJournal Articlelld:pubmed
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