Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1988-1-7
|
pubmed:abstractText |
This study evaluates prospectively the effect of parathyroidectomy on basal acid output (BAO), maximal acid output (MAO), fasting serum gastrin, secretin-stimulated serum gastrin, and sensitivity to antisecretory medication in 10 consecutive patients with primary hyperparathyroidism (PHP), Zollinger-Ellison syndrome (ZES), and multiple endocrine neoplasia type I (MEN-I). After parathyroidectomy, 9 of 10 patients remained normocalcemic, and each had a lower BAO; 6 of 9 no longer had gastric acid hypersecretion (less than 15 mEq/hr). Seven of 9 normocalcemic patients had a lower MAO, and a decrease in fasting serum gastrin. Two patients showed no evidence of ZES, a normal BAO, normal fasting serum gastrin concentration, and a negative secretin response after parathyroidectomy. Parathyroidectomy also reduced the dose of histamine H2-receptor antagonist required to control gastric acid secretion in 60% of patients. After successful parathyroidectomy three patients were studied for drug sensitivity, and each had greater acid inhibition with a given dose of histamine H2-receptor antagonist than preoperatively. One patient remained hypercalcemic after surgery and had no change in BAO, MAO, or gastrin. All patients with postoperative normocalcemia will have a lower BAO, 80% a lower MAO, 80% a decreased fasting serum gastrin, and 33% a negative secretin test. Antisecretory medication dose can be reduced because patients have reduced BAO and increased sensitivity to histamine H2-receptor antagonist. The study supports parathyroidectomy as the initial surgical procedure of choice in patients with PHP, ZES, and MEN-I.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0039-6060
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
102
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
958-66
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:2891201-Adult,
pubmed-meshheading:2891201-Female,
pubmed-meshheading:2891201-Gastric Acid,
pubmed-meshheading:2891201-Gastrins,
pubmed-meshheading:2891201-Histamine H2 Antagonists,
pubmed-meshheading:2891201-Humans,
pubmed-meshheading:2891201-Hyperparathyroidism,
pubmed-meshheading:2891201-Male,
pubmed-meshheading:2891201-Middle Aged,
pubmed-meshheading:2891201-Multiple Endocrine Neoplasia,
pubmed-meshheading:2891201-Parathyroid Glands,
pubmed-meshheading:2891201-Prospective Studies,
pubmed-meshheading:2891201-Zollinger-Ellison Syndrome
|
pubmed:year |
1987
|
pubmed:articleTitle |
Effect of parathyroidectomy in patients with hyperparathyroidism, Zollinger-Ellison syndrome, and multiple endocrine neoplasia type I: a prospective study.
|
pubmed:affiliation |
Surgery Branch, National Cancer Institute, Bethesda, MD 20892.
|
pubmed:publicationType |
Journal Article
|