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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1987-12-11
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pubmed:abstractText |
The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0740-7750
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
671-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:2890215-Animals,
pubmed-meshheading:2890215-Chromosome Mapping,
pubmed-meshheading:2890215-DNA,
pubmed-meshheading:2890215-Disease Models, Animal,
pubmed-meshheading:2890215-Genetic Linkage,
pubmed-meshheading:2890215-Humans,
pubmed-meshheading:2890215-Mice,
pubmed-meshheading:2890215-Muscular Dystrophy, Animal,
pubmed-meshheading:2890215-Mutation,
pubmed-meshheading:2890215-Nucleic Acid Hybridization,
pubmed-meshheading:2890215-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2890215-Species Specificity,
pubmed-meshheading:2890215-X Chromosome
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pubmed:year |
1987
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pubmed:articleTitle |
Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome.
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pubmed:affiliation |
Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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