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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1987-11-25
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pubmed:databankReference |
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pubmed:abstractText |
Gastric inhibitory polypeptide (GIP) is a 42-amino acid hormone that stimulates insulin secretion in the presence of glucose. Complementary DNA clones encoding human GIP were isolated from a library prepared with RNA from duodenum. The predicted amino acid sequence indicates that GIP is derived by proteolytic processing of a 153-residue precursor, preproGIP. The GIP moiety is flanked by polypeptide segments of 51 and 60 amino acids at its NH2 and COOH termini, respectively. The former includes a signal peptide of about 21 residues and an NH2-terminal propeptide of 30 amino acids. GIP is released from the precursor by processing at single arginine residues. There is a region of nine amino acids in the COOH-terminal propeptide of the GIP precursor that has partial homology with a portion of chromogranin A as well as pancreastatin.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-1193309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-265521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-3018587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-3092195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-3516723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-3537810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-3755681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-383576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-4551806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-4574902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-4749457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-5545261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-5761841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6192430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6206780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6287227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6345794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6391923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6415488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6571696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-659629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6745415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6847620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6877358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6994549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-6997135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-7023366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-7071021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-7227513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-7353457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-794758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-822353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-830237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-881736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2890159-954669
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromogranin A,
http://linkedlifedata.com/resource/pubmed/chemical/Chromogranins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Gastric Inhibitory Polypeptide,
http://linkedlifedata.com/resource/pubmed/chemical/Pancreatic Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Poly A,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Sorting Signals,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/pancreastatin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
7005-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2890159-Amino Acid Sequence,
pubmed-meshheading:2890159-Base Sequence,
pubmed-meshheading:2890159-Chromogranin A,
pubmed-meshheading:2890159-Chromogranins,
pubmed-meshheading:2890159-DNA,
pubmed-meshheading:2890159-Duodenum,
pubmed-meshheading:2890159-Gastric Inhibitory Polypeptide,
pubmed-meshheading:2890159-Molecular Sequence Data,
pubmed-meshheading:2890159-Pancreatic Hormones,
pubmed-meshheading:2890159-Poly A,
pubmed-meshheading:2890159-Protein Precursors,
pubmed-meshheading:2890159-Protein Sorting Signals,
pubmed-meshheading:2890159-RNA, Messenger,
pubmed-meshheading:2890159-Sequence Homology, Nucleic Acid
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pubmed:year |
1987
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