| pubmed-article:2888883 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C0007450 | lld:lifeskim |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C0086526 | lld:lifeskim |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C0333051 | lld:lifeskim |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:2888883 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2888883 | pubmed:dateCreated | 1987-11-19 | lld:pubmed |
| pubmed-article:2888883 | pubmed:abstractText | 1. Adult cats were anaesthetized with a mixture of halothane, nitrous oxide and oxygen to record from single neurones of the dorsal lateral geniculate nucleus (d.l.g.n.) with five-barrel glass micro-electrodes. Periphery effects (shift effects) were elicited by large-field phase-reversing gratings presented in the visual field outside the conventional receptive field area. 2. A range of transient excitatory responses was found in X and Y cells. Y cells had phasic shift effects with significantly higher amplitudes and shorter durations (mean 52 impulses/s, 135 ms) than those observed in the tonic shift effects of X cells (mean 24 impulses/s, 169 ms). All Y cells and most X cells responded to stimulation of remote retinal regions. About 7% of the X cells displayed no shift effect. 3. Micro-ionophoresis of the gamma-aminobutyric acid (GABA) antagonist bicuculline, acetylcholine (ACh) and L-glutamate specifically influenced the shift effects of X and Y cells. 4. During continuous application of the GABA antagonist bicuculline the differences in maximal response rates and amplitudes of X and Y cells were eliminated. The maintained activity raised predominantly in X cells and the early peak rates increased more in X- than in Y-cell shift effects, leading to equal average peak rates of 100 and response amplitudes of about 85 impulses/s in both cell classes. The characteristic time courses of X- and Y-cell responses were not affected. 5. Micro-ionophoretic application of ACh caused a combination of excitatory and disinhibitory effects. Maintained activity as well as early parts of stimulus-evoked responses were similarly raised in X and Y cells. In addition, the Y-cell shift effects became less phasic by elevation of the late response part. Sodium pentobarbitone, used to block ACh excitation, suppressed the ACh-induced effects in the early phase of the X- and Y-cell shift effects and the increase of maintained activity in Y-cells, while the effect on the late part of Y-cell responses persisted. Elevation of background activity partially remained in X cells, and the X-cell responses became tonically prolonged at the same time. 6. L-Glutamate increased the activity of X and Y cells without changing the characteristic shift-effect properties of both cell classes. 7. It is concluded that different short- and long-lasting inhibitory mechanisms shape the responses of d.l.g.n. neurones to stimulation outside the conventional receptive field.(ABSTRACT TRUNCATED AT 400 WORDS) | lld:pubmed |
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| pubmed-article:2888883 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2888883 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2888883 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2888883 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2888883 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2888883 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:2888883 | pubmed:author | pubmed-author:EyselU TUT | lld:pubmed |
| pubmed-article:2888883 | pubmed:author | pubmed-author:MuriRR | lld:pubmed |
| pubmed-article:2888883 | pubmed:author | pubmed-author:Van SchayckRR | lld:pubmed |
| pubmed-article:2888883 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2888883 | pubmed:volume | 388 | lld:pubmed |
| pubmed-article:2888883 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2888883 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2888883 | pubmed:pagination | 199-212 | lld:pubmed |
| pubmed-article:2888883 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2888883 | pubmed:meshHeading | pubmed-meshheading:2888883-... | lld:pubmed |
| pubmed-article:2888883 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2888883 | pubmed:articleTitle | Contributions of inhibitory mechanisms to the shift responses of X and Y cells in the cat lateral geniculate nucleus. | lld:pubmed |
| pubmed-article:2888883 | pubmed:affiliation | Department of Physiology, University of Essen, F.R.G. | lld:pubmed |
| pubmed-article:2888883 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2888883 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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