Linked Life Data

2888883

Source:http://linkedlifedata.com/resource/pubmed/id/2888883

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-11-19
pubmed:abstractText
1. Adult cats were anaesthetized with a mixture of halothane, nitrous oxide and oxygen to record from single neurones of the dorsal lateral geniculate nucleus (d.l.g.n.) with five-barrel glass micro-electrodes. Periphery effects (shift effects) were elicited by large-field phase-reversing gratings presented in the visual field outside the conventional receptive field area. 2. A range of transient excitatory responses was found in X and Y cells. Y cells had phasic shift effects with significantly higher amplitudes and shorter durations (mean 52 impulses/s, 135 ms) than those observed in the tonic shift effects of X cells (mean 24 impulses/s, 169 ms). All Y cells and most X cells responded to stimulation of remote retinal regions. About 7% of the X cells displayed no shift effect. 3. Micro-ionophoresis of the gamma-aminobutyric acid (GABA) antagonist bicuculline, acetylcholine (ACh) and L-glutamate specifically influenced the shift effects of X and Y cells. 4. During continuous application of the GABA antagonist bicuculline the differences in maximal response rates and amplitudes of X and Y cells were eliminated. The maintained activity raised predominantly in X cells and the early peak rates increased more in X- than in Y-cell shift effects, leading to equal average peak rates of 100 and response amplitudes of about 85 impulses/s in both cell classes. The characteristic time courses of X- and Y-cell responses were not affected. 5. Micro-ionophoretic application of ACh caused a combination of excitatory and disinhibitory effects. Maintained activity as well as early parts of stimulus-evoked responses were similarly raised in X and Y cells. In addition, the Y-cell shift effects became less phasic by elevation of the late response part. Sodium pentobarbitone, used to block ACh excitation, suppressed the ACh-induced effects in the early phase of the X- and Y-cell shift effects and the increase of maintained activity in Y-cells, while the effect on the late part of Y-cell responses persisted. Elevation of background activity partially remained in X cells, and the X-cell responses became tonically prolonged at the same time. 6. L-Glutamate increased the activity of X and Y cells without changing the characteristic shift-effect properties of both cell classes. 7. It is concluded that different short- and long-lasting inhibitory mechanisms shape the responses of d.l.g.n. neurones to stimulation outside the conventional receptive field.(ABSTRACT TRUNCATED AT 400 WORDS)
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-13716436, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-14223976, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-163117, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-191574, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-2868910, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-2870178, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-2985418, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-2990981, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-4005608, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-4034089, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-4293788, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-4313890, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-4315066, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-4338566, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-4352727, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-4435066, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-458660, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-4686020, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-4702151, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-501605, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-5016590, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-5097609, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-5360609, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-6124634, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-631241, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-6376726, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-6381084, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-6512702, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-6640295, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-6641846, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-6652490, http://linkedlifedata.com/resource/pubmed/commentcorrection/2888883-894539
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:volume
388
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-212
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Contributions of inhibitory mechanisms to the shift responses of X and Y cells in the cat lateral geniculate nucleus.
pubmed:affiliation
Department of Physiology, University of Essen, F.R.G.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't