Linked Life Data

2888567

Source:http://linkedlifedata.com/resource/pubmed/id/2888567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-11-18
pubmed:abstractText
1. Cardiotoxic effects of catecholamines in guinea-pigs and rats were compared. Substantially lesser cardiotoxic effects of isoprenaline (2 X 40 mg/kg b.w.) were found in guinea-pigs, as judged by morphologic examination. 2. When isolated hearts were perfused in vitro, noradrenaline (5 X 10(-6) M) induced less damage, judged by enzyme leakage (ASAT) and electron microscopy analysis. 3. Myocardial ATP and creatine phosphate are normally higher in guinea-pigs than in rats, and no difference was found between the two species when subjected to noradrenaline. 4. Glycogen was higher in guinea-pig myocardium, and glycogenolysis during noradrenaline perfusion was substantially greater in guinea-pig hearts than in rat hearts. 5. Obtained data are interpreted with respect to the recent findings that, not only natural history, but also some physiological traits [blood gas transporting system (Kreuzer and Turek, 1981, Medizinische Aspekte der Höhe, pp. 15-23)] make guinea-pigs similar to high altitude mammals, and to earlier findings that high altitude hypoxia adapted rats display lesser vulnerability of cardiac muscle by anoxia and by catecholamines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0742-8413
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-74
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Cardiotoxic effects of catecholamines in guinea-pig (Cavia porcellus) and in albino rat (Rattus norvegicus). A comparative study.
pubmed:affiliation
Department of Medicine, Academic Hospital, Uppsala, Sweden.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't