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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8559
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pubmed:dateCreated |
1987-10-15
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pubmed:abstractText |
114 haemodynamically stable patients with acute head injury were randomised, double-blind, to either placebo or atenolol given intravenously (10 mg every 6 h) for 3 days then orally (100 mg daily) for a further 4 days. Both groups were equally stressed as shown by raised arterial noradrenaline levels. In patients receiving placebo, but not in those receiving atenolol, there was a significant (p less than 0.01) positive correlation between arterial noradrenaline and levels of the myocardial isoenzyme of creatine kinase (CKMB). 30% of the placebo group compared with 7.4% of the atenolol group (p less than 0.05) showed CKMB levels greater than 3% of total creatine kinase (compatible with myocardial damage). CKMB levels greater than 6% of total creatine kinase (compatible with acute myocardial infarction) were present in 16.7% of patients receiving placebo but in no patients receiving atenolol (p = 0.053). Atenolol appeared to reduce significantly the likelihood of supraventricular tachycardia and ST-segment and T-wave changes and prevented cardiac necrosis seen at necropsy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
585-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2887885-Adolescent,
pubmed-meshheading:2887885-Adrenergic beta-Antagonists,
pubmed-meshheading:2887885-Adult,
pubmed-meshheading:2887885-Aged,
pubmed-meshheading:2887885-Atenolol,
pubmed-meshheading:2887885-Child,
pubmed-meshheading:2887885-Clinical Trials as Topic,
pubmed-meshheading:2887885-Craniocerebral Trauma,
pubmed-meshheading:2887885-Creatine Kinase,
pubmed-meshheading:2887885-Double-Blind Method,
pubmed-meshheading:2887885-Electrocardiography,
pubmed-meshheading:2887885-Female,
pubmed-meshheading:2887885-Follow-Up Studies,
pubmed-meshheading:2887885-Humans,
pubmed-meshheading:2887885-Isoenzymes,
pubmed-meshheading:2887885-Male,
pubmed-meshheading:2887885-Middle Aged,
pubmed-meshheading:2887885-Myocardium,
pubmed-meshheading:2887885-Necrosis,
pubmed-meshheading:2887885-Norepinephrine,
pubmed-meshheading:2887885-Pilot Projects,
pubmed-meshheading:2887885-Random Allocation,
pubmed-meshheading:2887885-Stress, Physiological,
pubmed-meshheading:2887885-Tachycardia, Supraventricular
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pubmed:year |
1987
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pubmed:articleTitle |
Reduction of stress/catecholamine-induced cardiac necrosis by beta 1-selective blockade.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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