Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1987-8-28
|
| pubmed:abstractText |
After ip administration of 15 mg/kg [1,4-14C]busulfan to rat, the urinary excretion was 70% of the total radioactivity after 72 hr. Three major metabolites were isolated and quantified by HPLC. Of the total radioactivity in the urine, unchanged busulfan was excreted as a minor amount (6%) and the following metabolites were identified as: 3-hydroxysulfolane (39%), tetrahydrothiophene 1-oxide (20%), and sulfolane (13%) using GC/MS and NMR spectroscopy. The cytotoxicity of busulfan and its major metabolites was examined using a V79 Chinese hamster cell line.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0090-9556
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
399-402
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2886318-Animals,
pubmed-meshheading:2886318-Busulfan,
pubmed-meshheading:2886318-Carbon Radioisotopes,
pubmed-meshheading:2886318-Chromatography, High Pressure Liquid,
pubmed-meshheading:2886318-Glutathione,
pubmed-meshheading:2886318-Male,
pubmed-meshheading:2886318-Rats,
pubmed-meshheading:2886318-Rats, Inbred Strains
|
| pubmed:articleTitle |
Urinary metabolites of busulfan in the rat.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|