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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4811
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pubmed:dateCreated |
1987-8-13
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pubmed:abstractText |
A wide variety of human tumors contain an amplified or overexpressed erbB-2 gene, which encodes a growth factor receptor-like protein. When erbB-2 complementary DNA was expressed in NIH/3T3 cells under the control of the SV40 promoter, the gene lacked transforming activity despite expression of detectable levels of the erbB-2 protein. A further five- to tenfold increase in its expression under influence of the long terminal repeat of Moloney murine leukemia virus was associated with activation of erbB-2 as a potent oncogene. The high levels of the erbB-2 product associated with malignant transformation of NIH/3T3 cells were observed in human mammary tumor cells that overexpressed this gene. These findings demonstrate a new mechanism for acquisition of oncogenic properties by genes encoding growth factor receptor-like proteins and provide a functional basis for the role of their overexpression in the development of human malignancies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
237
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
178-82
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2885917-Animals,
pubmed-meshheading:2885917-Breast Neoplasms,
pubmed-meshheading:2885917-Cell Line,
pubmed-meshheading:2885917-Cell Transformation, Neoplastic,
pubmed-meshheading:2885917-DNA,
pubmed-meshheading:2885917-Fibroblasts,
pubmed-meshheading:2885917-Gene Expression Regulation,
pubmed-meshheading:2885917-Genes, Viral,
pubmed-meshheading:2885917-Humans,
pubmed-meshheading:2885917-Mice,
pubmed-meshheading:2885917-Moloney murine leukemia virus,
pubmed-meshheading:2885917-Promoter Regions, Genetic,
pubmed-meshheading:2885917-Proto-Oncogene Proteins,
pubmed-meshheading:2885917-Rats,
pubmed-meshheading:2885917-Receptor, Epidermal Growth Factor,
pubmed-meshheading:2885917-Receptor, erbB-2,
pubmed-meshheading:2885917-Receptors, Cell Surface,
pubmed-meshheading:2885917-Recombinant Fusion Proteins,
pubmed-meshheading:2885917-Simian virus 40,
pubmed-meshheading:2885917-Tumor Stem Cell Assay
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pubmed:year |
1987
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pubmed:articleTitle |
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells.
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pubmed:publicationType |
Journal Article,
Comparative Study
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