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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-6-26
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pubmed:abstractText |
Studies of the effects of thyroid hormones on the uptake of neurotransmitters by homogenates of rat cerebral cortex have revealed a significant competitive inhibition of neuronal uptake of [3H]GABA by thyroid hormones (T3 greater than T4 greater than rT3). The IC50 for inhibition of GABA uptake by T3 was estimated at 4 microM and that of T4 at 11 microns. GABA uptake in homogenates of cerebral cortex from hypothyroid rats was significantly enhanced over that of controls; however, uptake in tissues from hyperthyroid rats was not significantly diminished.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
0306-4530
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2884685-Animals,
pubmed-meshheading:2884685-Cerebral Cortex,
pubmed-meshheading:2884685-Depression, Chemical,
pubmed-meshheading:2884685-Male,
pubmed-meshheading:2884685-Neurotransmitter Agents,
pubmed-meshheading:2884685-Rats,
pubmed-meshheading:2884685-Rats, Inbred Strains,
pubmed-meshheading:2884685-Thyroid Hormones,
pubmed-meshheading:2884685-Thyroxine,
pubmed-meshheading:2884685-Triiodothyronine,
pubmed-meshheading:2884685-gamma-Aminobutyric Acid
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pubmed:year |
1987
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pubmed:articleTitle |
GABA uptake is inhibited by thyroid hormones: implications for depression.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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