Linked Life Data

2883819

Source:http://linkedlifedata.com/resource/pubmed/id/2883819

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-5-27
pubmed:abstractText
The effects of six nightly doses of temazepam (20 mg), nitrazepam (10 mg) and placebo on saccadic eye movements, critical flicker fusion threshold, choice reaction time and mood were studied in eight volunteers. Performance was measured on nights 1 and 6 of each treatment. Nitrazepam produced a residual performance impairment on night 1 that disappeared by night 6, despite higher serum concentrations of the drug on the sixth night of treatment. Temazepam, with a shorter elimination half-life, produced no significant performance impairment on night 1, but by night 6 a significant impairment of saccadic eye movements (p less than 0.05) was seen 1 hour after drug intake. We conclude that tolerance to the sedative action of nitrazepam developed over the 6-night period of the study. No evidence of tolerance was seen with temazepam. No residual effects of temazepam (20 mg) were seen the morning after the night-time drug administration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-1591
pubmed:author
pubmed:issnType
Print
pubmed:volume
332
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-26
pubmed:dateRevised
2008-2-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The effects of repeated doses of temazepam and nitrazepam on several measures of human performance.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't