Linked Life Data

2883022

Source:http://linkedlifedata.com/resource/pubmed/id/2883022

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-6-9
pubmed:abstractText
Spontaneously occurring thyroid neoplasms exhibiting solid and/or anaplastic growth patterns in the Syrian golden hamster have been thought to be derived from follicular cells. Eight neoplasms of this type have been analyzed immunohistochemically and have been classified as medullary thyroid carcinomas (MTC) on the basis of their content of calcitonin (CT). Well differentiated MTCs in this species were composed of polyhedral cells showing uniform CT immunoreactivity while the poorly differentiated MTCs most often had spindle patterns of growth with marked variation in CT immunoreactivity. Both well and poorly differentiated MTCs contained entrapped follicles which were CT negative. In contrast to MTC in the rat and in humans with familial MTC, the tumors in hamsters were not associated with C-cell hyperplasia. The Syrian golden hamster may, therefore, serve as a useful model to study the factors which are responsible for the development of spontaneous (non-familial) MTC.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-1513
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Medullary thyroid carcinoma in the Syrian golden hamster: an immunohistochemical study.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.