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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1987-4-27
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pubmed:abstractText |
The non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoters palytoxin and thapsigargin provoked a respiratory burst in porcine and human neutrophils. The amounts of oxygen consumed and superoxide anion (O2-) produced were found to be stoichiometric. Concentrations of 6.5 X 10(-8) M palytoxin and 1.2 X 10(-6) M thapsigargin were required for half-maximal stimulation to 3 X 10(6) porcine cells/ml in Hanks' solution. Combinations of palytoxin and thapsigargin, and of one non-TPA type and one TPA-type tumor promoter, had synergistic effects in stimulating O2- formation in neutrophils, suggesting that these compounds activate the cells by different signal transduction mechanisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acrylamides,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Cnidarian Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/Lyngbya Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/NADH, NADPH Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Thapsigargin,
http://linkedlifedata.com/resource/pubmed/chemical/palytoxin,
http://linkedlifedata.com/resource/pubmed/chemical/teleocidin
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
143
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
672-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2882751-Acrylamides,
pubmed-meshheading:2882751-Animals,
pubmed-meshheading:2882751-Carcinogens,
pubmed-meshheading:2882751-Cnidarian Venoms,
pubmed-meshheading:2882751-Humans,
pubmed-meshheading:2882751-Lyngbya Toxins,
pubmed-meshheading:2882751-NADH, NADPH Oxidoreductases,
pubmed-meshheading:2882751-NADPH Oxidase,
pubmed-meshheading:2882751-Oxygen Consumption,
pubmed-meshheading:2882751-Plant Extracts,
pubmed-meshheading:2882751-Superoxides,
pubmed-meshheading:2882751-Swine,
pubmed-meshheading:2882751-Tetradecanoylphorbol Acetate,
pubmed-meshheading:2882751-Thapsigargin
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pubmed:year |
1987
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pubmed:articleTitle |
Stimulation of superoxide anion formation by the non-TPA type tumor promoters palytoxin and thapsigargin in porcine and human neutrophils.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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