Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1987-4-28
|
| pubmed:abstractText |
The restriction fragment length polymorphism of the unrearranged T-cell antigen receptor (Tcr) alpha chain gene was investigated. Taq I digests, when probed with a Tcr alpha chain cDNA probe, revealed polymorphic bands of 7.0, 2.0, and 1.4 kb, due to variations around the C alpha gene, and the V gene cluster. Family studies confirmed the segregation of these polymorphic bands as allelic markers. These polymorphisms provide a new marker for the analysis of genetic variation of the Tcr alpha chain, and the influence of variation of the Tcr genes on the immune response.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0093-7711
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
141-4
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2881883-Alleles,
pubmed-meshheading:2881883-Chromosome Mapping,
pubmed-meshheading:2881883-Genes,
pubmed-meshheading:2881883-Humans,
pubmed-meshheading:2881883-Pedigree,
pubmed-meshheading:2881883-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2881883-Receptors, Antigen, T-Cell
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
A new polymorphic marker of the T-cell antigen receptor alpha chain genes in man.
|
| pubmed:publicationType |
Journal Article
|