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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1987-4-23
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pubmed:abstractText |
Six adult patients had a chronic progressive myelopathy that possessed the following features: high antibody titers to human T-lymphotropic virus type I (HTLV-I) in serum and cerebrospinal fluid (CSF); predominantly upper motor neuron disorder, symmetrical, with mild sensory and bladder disturbances; and presence of adult T-cell leukemia-like cells in both peripheral blood and CSF. We refer to this entity as HTLV-I-associated myelopathy (HAM). Electrophoretic studies of immunoglobulin G in CSF using Western blot analysis characteristically demonstrated p24 and p32 bands. Rates of intra-blood-brain barrier synthesis were determined and found increased in the patients with HAM. Corticosteroid treatment produced clinical improvement in all of 4 patients. A retrospective survey of CSF samples was carried out in 287 patients with neurological disorders, and 6 additional patients with HAM were identified.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0364-5134
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2881513-Adrenal Cortex Hormones,
pubmed-meshheading:2881513-Antibodies, Viral,
pubmed-meshheading:2881513-Blood-Brain Barrier,
pubmed-meshheading:2881513-Chronic Disease,
pubmed-meshheading:2881513-Deltaretrovirus,
pubmed-meshheading:2881513-Deltaretrovirus Infections,
pubmed-meshheading:2881513-Humans,
pubmed-meshheading:2881513-Immunoglobulin G,
pubmed-meshheading:2881513-Spinal Cord Diseases
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pubmed:year |
1987
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pubmed:articleTitle |
Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemialike cells.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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