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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1987-4-3
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pubmed:abstractText |
Recent evidence shows that mature Thy-1 glycoprotein lacks amino acids 113-143 predicted from the cDNA sequence and is anchored to the plasma membrane by a phosphatidylinositol-containing glycolipid attached to amino acid 112. Previously characterized Thy-1-deficient mutant lymphoma lines of complementation classes A and E were analysed. They make detergent binding Thy-1 precursors but, in contrast to wild-type, the detergent binding moiety cannot be removed by phospholipase C. Moreover, tryptophan which only occurs at position 124 is incorporated into mutant but not parental Thy-1. This suggests that the mutants make a Thy-1 precursor of 143 amino acids but fail to replace its C-terminal end by a glycolipid anchor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-10986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-14207060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-163833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-2581790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-2856927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-2857477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-2857501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-2858198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-2859851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-2865681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-2865810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-2934386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-3709520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-3753980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-3858818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-3886166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-3896676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-4544550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-4702114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-6142077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-6147849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-6151686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-6163818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-6177036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-61881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-6257680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-6272213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-667934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-6812050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-710496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-7372584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2880714-7442811
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3291-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2880714-Animals,
pubmed-meshheading:2880714-Antigens, Surface,
pubmed-meshheading:2880714-Antigens, Thy-1,
pubmed-meshheading:2880714-Cell Line,
pubmed-meshheading:2880714-Cell Membrane,
pubmed-meshheading:2880714-DNA,
pubmed-meshheading:2880714-Female,
pubmed-meshheading:2880714-Lymphoma,
pubmed-meshheading:2880714-Membrane Proteins,
pubmed-meshheading:2880714-Mice,
pubmed-meshheading:2880714-Mice, Inbred C57BL,
pubmed-meshheading:2880714-Mutation,
pubmed-meshheading:2880714-Neoplasm Proteins,
pubmed-meshheading:2880714-Phosphatidylinositols
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pubmed:year |
1986
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pubmed:articleTitle |
Anchoring of membrane proteins via phosphatidylinositol is deficient in two classes of Thy-1 negative mutant lymphoma cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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