Linked Life Data

2880346

Source:http://linkedlifedata.com/resource/pubmed/id/2880346

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-3-6
pubmed:abstractText
Neuroendocrine abnormalities in depression have been regarded, by many authors, as relatively specific markers of nosological subtypes of the disorder, e.g. primary vs. secondary, endogenous vs. non-endogenous or unipolar vs. bipolar depression. They should reflect the same changes in central neurotransmitters (e.g. noradrenergic insufficiency and/or cholinergic hyperactivity) that were hypothesized as the cause of clinical symptoms. This view is challenged on the basis of our own neuroendocrine investigations in 317 psychiatric patients and 103 normal controls. According to these studies the abnormalities are nosologically rather unspecific. They are induced by a large variety of factors, e.g. emotional stress associated with the clinical symptomatology, weight loss due to malnutrition as a consequence of reduced appetite, medication and drug withdrawal. Stress-induced hypercortisolism appears to be the most common abnormality that may trigger other neuroendocrine dysfunctions, such as a blunted TSH response to TRH. Differences in neuroendocrine abnormalities of depressives are probably due to variations in the manifold factors influencing the hormonal axes involved, to temporal changes in hormonal patterns (e.g. one abnormality triggering another) and to individual differences in the basic activity and the responsiveness of the various axes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0262-9283
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
237-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:2880346-Adrenocortical Hyperfunction, pubmed-meshheading:2880346-Adrenocorticotropic Hormone, pubmed-meshheading:2880346-Body Weight, pubmed-meshheading:2880346-Depressive Disorder, pubmed-meshheading:2880346-Dexamethasone, pubmed-meshheading:2880346-Growth Hormone, pubmed-meshheading:2880346-Hormones, pubmed-meshheading:2880346-Humans, pubmed-meshheading:2880346-Hypothalamo-Hypophyseal System, pubmed-meshheading:2880346-Mental Disorders, pubmed-meshheading:2880346-Neurotransmitter Agents, pubmed-meshheading:2880346-Pituitary-Adrenal System, pubmed-meshheading:2880346-Psychotropic Drugs, pubmed-meshheading:2880346-Stress, Psychological, pubmed-meshheading:2880346-Substance Withdrawal Syndrome, pubmed-meshheading:2880346-Thyrotropin, pubmed-meshheading:2880346-Thyrotropin-Releasing Hormone
pubmed:year
1986
pubmed:articleTitle
The nature of neuroendocrine abnormalities in depression: a controversial issue in contemporary psychiatry.
pubmed:publicationType
Journal Article