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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1987-2-11
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pubmed:abstractText |
Specific binding sites for somatostatin have been characterized in cytosolic fraction of rabbit renal papilla. The interaction of 125I-Tyr11-somatostatin with cytosolic fraction was rapid, reversible, specific, saturable and dependent on temperature. At 25 degrees C the binding data were compatible with the existence of two classes of binding sites: a high-affinity class with a Kd = 57.7 nM and a low-affinity class with a Kd = 217.4 nM. Somatostatin binding sites exhibited a high degree of specificity since neuropeptides such as Leu-enkephalin, neurotensin, substance P, vasopressin and vasoactive intestinal peptide behaved as ligands with null or very low affinity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0196-9781
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
741-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2879274-Animals,
pubmed-meshheading:2879274-Binding, Competitive,
pubmed-meshheading:2879274-Cytosol,
pubmed-meshheading:2879274-Kidney,
pubmed-meshheading:2879274-Kinetics,
pubmed-meshheading:2879274-Male,
pubmed-meshheading:2879274-Neuropeptides,
pubmed-meshheading:2879274-Rabbits,
pubmed-meshheading:2879274-Receptors, Neurotransmitter,
pubmed-meshheading:2879274-Receptors, Somatostatin,
pubmed-meshheading:2879274-Somatostatin
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pubmed:articleTitle |
Interaction of somatostatin with isolated cytosol from rabbit renal papilla.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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