Linked Life Data

2878531

Source:http://linkedlifedata.com/resource/pubmed/id/2878531

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-1-13
pubmed:abstractText
The ultracytochemical changes induced in the pancreas by a single large dose of lysine (400 mg/100 g body weight) were studied in male Wistar rats of 7 weeks old. The first changes in the acinar cells were marked swelling of mitochondria with increase in their calcium content and decrease in their ATP content. Early calcium deposits seemed to occur in the matrices of swollen mitochondria and later various patterns occurred. These findings suggested that damage of the acinar cells by excess lysine resulted in breakdown of the mitochondrial membrane barrier to calcium as a very early abnormality, and that extracellular calcium then entered the mitochondrial matrices and inhibited mitochondrial function. Subsequently focal areas of the cytoplasm were degraded. Autophagic vacuoles appeared in these areas, and then acid phosphatase activity in their periphery as a result of fusion with lysosomes. The reaction of acid phosphatase was demonstrated in the locally degraded rough endoplasmic reticulum within or around autophagic vacuoles, suggesting that the endoplasmic reticulum as well as lysosomes participated in the intracellular degradation of cytoplasmic organelles in damaged acinar cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-6075
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-67
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Ultracytochemistry of pancreatic damage induced by excess lysine.
pubmed:publicationType
Journal Article