| pubmed-article:2878387 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C0028633 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C0039067 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C0040615 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C0206129 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:2878387 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:2878387 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2878387 | pubmed:dateCreated | 1987-1-2 | lld:pubmed |
| pubmed-article:2878387 | pubmed:abstractText | The release of preloaded [3H]dopamine (DA) from superfused synaptosomes stimulated by 30 mM K+ was investigated in the nucleus accumbens of rats. Under conditions preventing the uptake of DA (presence of 40 microM cocaine) release of [3H]DA was inhibited by DA and apomorphine in a concentration-dependent manner (IC50s 0.65 and 0.3 microM, respectively). The maximal inhibitory effects of DA, as well as of apomorphine, were about 50% of the controls. The DA-induced inhibition was antagonized by antipsychotics completely; the rank order of antagonistic potencies was haloperidol greater than clozapine greater than sulpiride; methiothepine was ineffective. Furthermore, the K+-stimulated release of [3H]DA was inhibited by serotonin in a concentration-dependent manner (IC50 = 0.9 microM). This inhibitory effect was antagonized by methiothepine with a high efficiency, by clozapine and methysergide with moderate efficiencies; haloperidol and sulpiride were ineffective. The experimental system demonstrated appears to be suitable for characterizing the DA- and serotonin-antagonistic potencies of antipsychotics and other drugs on presynaptic autoreceptors as well as receptors modulating release of DA in the nucleus accumbens. | lld:pubmed |
| pubmed-article:2878387 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2878387 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2878387 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2878387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2878387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2878387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2878387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2878387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2878387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2878387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2878387 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2878387 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2878387 | pubmed:issn | 0028-3908 | lld:pubmed |
| pubmed-article:2878387 | pubmed:author | pubmed-author:DrescherKK | lld:pubmed |
| pubmed-article:2878387 | pubmed:author | pubmed-author:HeteyLL | lld:pubmed |
| pubmed-article:2878387 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2878387 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:2878387 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2878387 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2878387 | pubmed:pagination | 1103-9 | lld:pubmed |
| pubmed-article:2878387 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2878387 | pubmed:meshHeading | pubmed-meshheading:2878387-... | lld:pubmed |
| pubmed-article:2878387 | pubmed:meshHeading | pubmed-meshheading:2878387-... | lld:pubmed |
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| pubmed-article:2878387 | pubmed:meshHeading | pubmed-meshheading:2878387-... | lld:pubmed |
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| pubmed-article:2878387 | pubmed:meshHeading | pubmed-meshheading:2878387-... | lld:pubmed |
| pubmed-article:2878387 | pubmed:meshHeading | pubmed-meshheading:2878387-... | lld:pubmed |
| pubmed-article:2878387 | pubmed:meshHeading | pubmed-meshheading:2878387-... | lld:pubmed |
| pubmed-article:2878387 | pubmed:meshHeading | pubmed-meshheading:2878387-... | lld:pubmed |
| pubmed-article:2878387 | pubmed:meshHeading | pubmed-meshheading:2878387-... | lld:pubmed |
| pubmed-article:2878387 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2878387 | pubmed:articleTitle | Influence of antipsychotics on presynaptic receptors modulating the release of dopamine in synaptosomes of the nucleus accumbens of rats. | lld:pubmed |
| pubmed-article:2878387 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2878387 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2878387 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2878387 | lld:pubmed |
