Linked Life Data

2877900

Source:http://linkedlifedata.com/resource/pubmed/id/2877900

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-1-21
pubmed:abstractText
Chronic administration of cocaine (10 mg/kg, i.p., every 12 h for 10 consecutive days) produced a large decrease in tyrosine hydroxylase-staining axons and terminal boutons in the caudate nucleus in rats when examined 60 days after the final cocaine injection. This effect was quantitated using the Leitz data acquisition and display system (DADS) which revealed that there was a 63% decrease in tyrosine hydroxylase-positive processes in the caudate nucleus. In addition, this cocaine treatment regimen produced a large decrease in the number of tyrosine hydroxylase-positive staining neuronal perikarya in the pars compacta of the substantia nigra. Use of the Leitz-DADS system revealed that there was a 51% decrease in tyrosine hydroxylase-positive material in the substantia nigra. These data demonstrated that chronic administration of cocaine produced a long-term loss of tyrosine hydroxylase in both the cell bodies of the substantia nigra and the nerve terminals of the caudate nucleus. Further studies are required to determine whether the observed changes are due to degeneration of the neurons or some metabolic effect.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
744-56
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Chronic cocaine administration depletes tyrosine hydroxylase immunoreactivity in the rat brain nigral striatal system: quantitative light microscopic studies.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.