Linked Life Data

2877551

Source:http://linkedlifedata.com/resource/pubmed/id/2877551

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-12-12
pubmed:abstractText
Native normal human serum is capable of inhibiting the cytotoxic action of Entamoeba histolytica against K562 tissue culture target cells assessed by a 51Cr-release test. It is suggested that a part of the inhibitory activity on amoebae's cytotoxic action is represented by the complement system which is known to lyze trophozoites by activation of the alternative pathway. For the rest of the serum's inhibitory activity on amoebic cytotoxic action molecule(s) is (are) responsible which act(s) independently of Mg2+ and Ca2+. The serum components have to act before the trophozoites have come in contact with the target cells. The opsonization of trophozoites with antiamoebic antibodies led to an inhibition of amoebae's cytotoxic action (ACA) in a dose-dependent manner. The inhibitory components of normal human serum and antiamoebic antibodies potentiated each other in their capacity to inhibit ACA. It is suggested that opsonization of amoebae with C3b via its metastable binding site leads to redistribution phenomena on the amoebae's surface similar to the effects observed with antiamoebic antibodies, both events leading to inhibition of ACA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0001-706X
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-54
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Interaction of serum components with the cytotoxic action of Entamoeba histolytica.
pubmed:publicationType
Journal Article