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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1986-10-30
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pubmed:abstractText |
The neuronal effects of somatostatin-14 (SS-14) and its influence on responses to acetylcholine (AcCho) were studied in vivo in the rat parietal cortex and dorsal hippocampus, using single-unit recording and microiontophoresis. SS-14 inhibited spontaneous firing of nearly all cells tested, while AcCho facilitated their firing. In contrast to its direct slowing effect, sustained iontophoretic application of SS-14 enhanced AcCho-induced excitations in 78% of all cells tested. This AcCho-enhancing effect of SS-14 was dose dependent. SS-14 did not enhance the responsiveness to pulses of the excitatory amino acid glutamate. Neurons tonically driven by iontophoretic currents of AcCho responded to concurrent pulses of SS-14 with an increase in firing. Thus, iontophoretic application of SS-14 can produce qualitatively different effects on the spontaneous activity of its target cells depending on the simultaneous effects of other chemical messengers. These condition-dependent interactions may explain the diverse neuronal effects of SS-14 reported in the literature.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-1126315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-26879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-2857791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-2867489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-2867600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-336149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-3866254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-3980786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-4368008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-4682131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6103812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6107913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6116516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6121326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6127997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6130476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6132664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6133919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6135179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6142651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6149275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-6149547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-643079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-679024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-687991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-861722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-861744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2876428-934439
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7518-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2876428-Acetylcholine,
pubmed-meshheading:2876428-Action Potentials,
pubmed-meshheading:2876428-Animals,
pubmed-meshheading:2876428-Cerebral Cortex,
pubmed-meshheading:2876428-Drug Synergism,
pubmed-meshheading:2876428-Glutamates,
pubmed-meshheading:2876428-Hippocampus,
pubmed-meshheading:2876428-Male,
pubmed-meshheading:2876428-Pyramidal Tracts,
pubmed-meshheading:2876428-Rats,
pubmed-meshheading:2876428-Somatostatin,
pubmed-meshheading:2876428-Synaptic Membranes
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pubmed:year |
1986
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pubmed:articleTitle |
Somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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