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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1986-11-19
|
| pubmed:abstractText |
The resolution of three 2-substituted derivatives of idazoxan is described. The enantiomers show large separations in activity in a variety of in vitro and in vivo tests, and the active isomers are all potent and selective antagonists at the alpha 2-adrenoreceptor. The significance of these results in relation to those published on the enantiomers of idazoxan and to those on optically active alpha 2-adrenoreceptor agonists is discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2000-3
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2876101-Adrenergic alpha-Antagonists,
pubmed-meshheading:2876101-Animals,
pubmed-meshheading:2876101-Dioxanes,
pubmed-meshheading:2876101-Dioxins,
pubmed-meshheading:2876101-Idazoxan,
pubmed-meshheading:2876101-Rats,
pubmed-meshheading:2876101-Stereoisomerism,
pubmed-meshheading:2876101-Structure-Activity Relationship
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists.
|
| pubmed:publicationType |
Journal Article
|