Linked Life Data

2876071

Source:http://linkedlifedata.com/resource/pubmed/id/2876071

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1986-11-7
pubmed:abstractText
The effect of punch velocity over the range 0.033-300 mm s-1 on the compaction properties of lactose, microcrystalline cellulose and a drug substance (a phthalazine derivative) for a range of particle sizes has been studied using the yield pressure derived from the Heckel relationship and a strain rate sensitivity index (SRS index), as the criteria to describe their behaviour. For lactose, a material which deforms by a mixed mechanism of particle fracture and plastic deformation at the contact points, the yield pressure increased and the SRS index decreased as particle size decreased, due to a reduction in the amount of fragmentation of the particles. For microcrystalline cellulose, a material which is known to deform plastically, the yield pressure and the SRS index were independent of particle size. For the phthalazine derivative the yield pressure increased as particle size decreased; however the SRS index reduced from 41% to zero, indicating that the deformation mechanism was changing from plastic flow to brittle behaviour. This decrease in the SRS index has been explained in terms of the relative amounts of strain-hardened material produced as milling severity increased, resulting in an increasing resistance to deformation and thus an apparent increase in brittle behaviour as particle size decreased.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-3573
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
567-71
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The effect of the relationship between punch velocity and particle size on the compaction behaviour of materials with varying deformation mechanisms.
pubmed:publicationType
Journal Article