rdf:type |
|
lifeskim:mentions |
umls-concept:C0025936,
umls-concept:C0039194,
umls-concept:C0085862,
umls-concept:C0871261,
umls-concept:C1299583,
umls-concept:C1524063,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
pubmed:issue |
7
|
pubmed:dateCreated |
1986-10-30
|
pubmed:abstractText |
We have introduced a mouse Thy-1.1 gene into the germline of Thy-1.2 mice. The introduced gene was shown to be expressed at very high levels in thymocytes when compared with the endogenous gene. Transgenic thymocytes were shown to evoke a higher than normal primary anti-Thy-1.1 antibody response in plaque-forming cell (PFC) assays. This result suggests that a direct quantitative interaction of the Thy-1 antigen activates the B cell response.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0022-1767
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
137
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2089-92
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2876039-Animals,
pubmed-meshheading:2876039-Antigens, Surface,
pubmed-meshheading:2876039-Antigens, T-Independent,
pubmed-meshheading:2876039-Antigens, Thy-1,
pubmed-meshheading:2876039-B-Lymphocytes,
pubmed-meshheading:2876039-Cloning, Molecular,
pubmed-meshheading:2876039-Gene Expression Regulation,
pubmed-meshheading:2876039-Isoantibodies,
pubmed-meshheading:2876039-Mice,
pubmed-meshheading:2876039-Mice, Inbred Strains,
pubmed-meshheading:2876039-T-Lymphocytes,
pubmed-meshheading:2876039-Thymus Gland,
pubmed-meshheading:2876039-Tissue Distribution,
pubmed-meshheading:2876039-Transfection
|
pubmed:year |
1986
|
pubmed:articleTitle |
T cell independent Thy-1 allo-antibody response with the use of transgenic mice.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|