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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3 Pt 2
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pubmed:dateCreated |
1986-10-21
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pubmed:abstractText |
Intracellular data were obtained from 35 supraoptic nucleus neurosecretory neurons maintained in vitro in intra-arterially perfused explants of rat hypothalamus. Addition of norepinephrine, phenylephrine, or methoxamine, but not isoproterenol (30-200 microM), consistently induced membrane depolarization, bursting activity, and an associated prolongation in action potential duration, effects that were reversibly antagonized by the alpha 1-antagonist prazosin. Norepinephrine-evoked depolarizations demonstrated no consistent change in membrane resistance and were reduced both by membrane hyperpolarization and by raising extracellular K+. Norepinephrine shortened the time course of spike hyperpolarizing afterpotentials and increased the magnitude of late depolarizing afterpotentials. It is proposed that one of norepinephrine's actions on supraoptic neurons involves K+ channels, perhaps by modulation of a transient K+ current known as A current.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
251
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R569-74
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2875661-Action Potentials,
pubmed-meshheading:2875661-Adrenergic alpha-Agonists,
pubmed-meshheading:2875661-Animals,
pubmed-meshheading:2875661-Electrophysiology,
pubmed-meshheading:2875661-Intracellular Membranes,
pubmed-meshheading:2875661-Neurons,
pubmed-meshheading:2875661-Neurosecretory Systems,
pubmed-meshheading:2875661-Norepinephrine,
pubmed-meshheading:2875661-Rats,
pubmed-meshheading:2875661-Receptors, Adrenergic, alpha,
pubmed-meshheading:2875661-Supraoptic Nucleus
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pubmed:year |
1986
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pubmed:articleTitle |
Alpha 1-adrenergic receptor activation depolarizes rat supraoptic neurosecretory neurons in vitro.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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