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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1986-9-17
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pubmed:abstractText |
Cimetidine and ranitidine are specific and potent H2-receptor antagonists widely used in the effective therapy of peptic ulcer disease. The drugs also possess other pharmacological properties unrelated to H2-receptor antagonism. More recently large experimental doses of cimetidine or ranitidine were found to have anticholinesterase, ganglion blocking and neuromuscular blocking activities. Actions of the drugs at such cholinergic sites may account for some of their clinically documented adverse effects. The toxicological implications of these findings including the potential for drug interactions to occur, especially during some anesthetic procedures, are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cholinesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cimetidine,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Ganglionic Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Neuromuscular Blocking Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Ranitidine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cholinergic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine H2
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
383-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2874464-Anesthesia,
pubmed-meshheading:2874464-Animals,
pubmed-meshheading:2874464-Antihypertensive Agents,
pubmed-meshheading:2874464-Bradycardia,
pubmed-meshheading:2874464-Cholinesterase Inhibitors,
pubmed-meshheading:2874464-Cimetidine,
pubmed-meshheading:2874464-Confusion,
pubmed-meshheading:2874464-Cytochrome P-450 Enzyme System,
pubmed-meshheading:2874464-Diarrhea,
pubmed-meshheading:2874464-Drug Interactions,
pubmed-meshheading:2874464-Erectile Dysfunction,
pubmed-meshheading:2874464-Ganglionic Blockers,
pubmed-meshheading:2874464-Hemodynamics,
pubmed-meshheading:2874464-Humans,
pubmed-meshheading:2874464-Male,
pubmed-meshheading:2874464-Mixed Function Oxygenases,
pubmed-meshheading:2874464-Neuromuscular Blocking Agents,
pubmed-meshheading:2874464-Peptic Ulcer,
pubmed-meshheading:2874464-Ranitidine,
pubmed-meshheading:2874464-Receptors, Cholinergic,
pubmed-meshheading:2874464-Receptors, Histamine H2,
pubmed-meshheading:2874464-Zollinger-Ellison Syndrome
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pubmed:year |
1986
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pubmed:articleTitle |
Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Review,
Research Support, Non-U.S. Gov't
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