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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8500
|
| pubmed:dateCreated |
1986-8-21
|
| pubmed:abstractText |
Human immunodeficiency virus antigen (HIV-Ag) was detected in the serum of most adult (13/16) and paediatric (6/6) AIDS patients and rarely in the serum of symptomless seropositive controls (1/13). It was present in the cerebrospinal fluid (CSF) of all 5 children and most (5/9) adults with AIDS-related encephalopathy, but not in the CSF of 13 symptomless seropositive controls, of whom 8 had antibody in the CSF. A longitudinal study of 1 of the controls with antibody in the CSF showed that HIV-Ag in CSF was present transiently before the occurrence of antibody in the CSF. In serial samples of serum from 35 men who seroconverted HIV-Ag was detected in 11 persons--in 5 before seroconversion and in 6 after. 3 of the 6 who became antigenaemic after seroconversion remained so for the rest of the follow-up. AIDS was diagnosed in 1 patient, 3 months after HIV-Ag was first detected in serum and 6 months after seroconversion. The findings suggest that HIV-Ag appears early and transiently in primary HIV infection. Antibody production follows, after which HIV-Ag may disappear. Its persistence or reappearance seems to correlate with clinical, immunological, and neurological deterioration.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
26
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
177-80
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2873436-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:2873436-Acute Disease,
pubmed-meshheading:2873436-Adult,
pubmed-meshheading:2873436-Antibodies, Viral,
pubmed-meshheading:2873436-Antigens, Viral,
pubmed-meshheading:2873436-Brain Diseases,
pubmed-meshheading:2873436-Child,
pubmed-meshheading:2873436-Child, Preschool,
pubmed-meshheading:2873436-Chronic Disease,
pubmed-meshheading:2873436-Deltaretrovirus,
pubmed-meshheading:2873436-Female,
pubmed-meshheading:2873436-HIV Antibodies,
pubmed-meshheading:2873436-HIV Antigens,
pubmed-meshheading:2873436-Homosexuality,
pubmed-meshheading:2873436-Humans,
pubmed-meshheading:2873436-Immunoassay,
pubmed-meshheading:2873436-Infant,
pubmed-meshheading:2873436-Male,
pubmed-meshheading:2873436-Middle Aged,
pubmed-meshheading:2873436-Prospective Studies,
pubmed-meshheading:2873436-Risk,
pubmed-meshheading:2873436-Time Factors
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Expression of human immunodeficiency virus antigen (HIV-Ag) in serum and cerebrospinal fluid during acute and chronic infection.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|