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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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|
pubmed:dateCreated |
1986-7-23
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pubmed:abstractText |
Antagonist activity of bulbocapnine on DA1 versus DA2 dopamine receptors was studied simultaneously in a dog under pentobarbitone anaesthesia and without phenoxybenzamine pretreatment. Fenoldopam (SK&F 82526) injected into the renal artery was the DA1 agonist and dipropyl dopamine or piribedil injected into the femoral artery were the DA2 agonists. Both at 0.5 and 1 mg kg-1 doses intravenous bulbocapnine caused nearly equal inhibition of DA1 and DA2 dopamine receptor-mediated responses. Our results show that under these experimental conditions bulbocapnine is not a selective DA1 dopamine antagonist.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
May
|
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pubmed:issn |
0022-3573
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
401-2
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2872323-Animals,
pubmed-meshheading:2872323-Aporphines,
pubmed-meshheading:2872323-Benzazepines,
pubmed-meshheading:2872323-Binding, Competitive,
pubmed-meshheading:2872323-Dogs,
pubmed-meshheading:2872323-Dopamine,
pubmed-meshheading:2872323-Fenoldopam,
pubmed-meshheading:2872323-Piribedil,
pubmed-meshheading:2872323-Receptors, Dopamine,
pubmed-meshheading:2872323-Vasodilator Agents
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pubmed:year |
1986
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|
pubmed:articleTitle |
Bulbocapnine is not a selective DA1 receptor antagonist.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
