Linked Life Data

2871895

Source:http://linkedlifedata.com/resource/pubmed/id/2871895

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-6-30
pubmed:abstractText
Facilitation of synaptic connections between sensory neurons and motor neurons mediating the tail withdrawal reflex in Aplysia is produced by the modulatory effects of sensitizing stimuli. Facilitation can be mimicked by perfusing these neurons with serotonin (5-HT) in a semi-intact preparation. Consequently, 5-HT has been presumed to be acting as an agonist of the modulatory transmitter that mediates sensitizing input in vivo. While the 5-HT effects appear to be mediated by increased cyclic adenosine monophosphate (cAMP) levels in the sensory neurons, a critical issue that has not been examined is whether sensitizing stimuli also increase cAMP levels in these cells. We now report that such sensitizing stimuli delivered to the tail of a semi-intact preparation lead to elevation of cAMP levels in the tail sensory neurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
371
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
190-2
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Stimuli that produce sensitization lead to elevation of cyclic AMP levels in tail sensory neurons of Aplysia.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.