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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3 Pt 2
|
pubmed:dateCreated |
1986-5-30
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pubmed:abstractText |
Bevantolol (the hydrochloride salt) has pharmacokinetic properties that are clinically advantageous. Bevantolol is well absorbed orally (greater than 70%); and the systemic bioavailability is 60%. Peak plasma concentrations are achieved 1 to 2 hours following an oral dose. Elimination is first-order with an average elimination half-life of 1.5 hours. Bevantolol exhibits linear pharmacokinetics within the therapeutic range (100 to 400 mg) with no change in half-life with chronic dosing. These properties result in predictable plasma levels and predictable drug response.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0003-3197
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2871781-Adrenergic beta-Antagonists,
pubmed-meshheading:2871781-Aged,
pubmed-meshheading:2871781-Aging,
pubmed-meshheading:2871781-Biological Availability,
pubmed-meshheading:2871781-Female,
pubmed-meshheading:2871781-Humans,
pubmed-meshheading:2871781-Intestinal Absorption,
pubmed-meshheading:2871781-Kinetics,
pubmed-meshheading:2871781-Male,
pubmed-meshheading:2871781-Propanolamines,
pubmed-meshheading:2871781-Sex Factors,
pubmed-meshheading:2871781-Tissue Distribution
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pubmed:year |
1986
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pubmed:articleTitle |
Clinical pharmacokinetics and metabolism of bevantolol.
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pubmed:publicationType |
Journal Article
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