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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-6-9
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pubmed:abstractText |
In anesthetized rats, injections of a 0.5 mM glutamate solution into the locus coeruleus (LC) reversibly increased the amplitude of the population spike evoked in CA1 by stimulation of the Schaffer-commissural fiber tract. This effect was absent in N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)-treated, noradrenaline (NA)-depleted animals. The excitatory postsynaptic potential recorded in the stratum radiatum was unaffected following the glutamate injections. Systemic administration of the NA-uptake inhibitor desipramine also produced an increase in population spike amplitude. The findings demonstrate that activation of LC neurons increases pyramidal cell excitability in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-6
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2871530-Animals,
pubmed-meshheading:2871530-Benzylamines,
pubmed-meshheading:2871530-Brain Mapping,
pubmed-meshheading:2871530-Desipramine,
pubmed-meshheading:2871530-Evoked Potentials,
pubmed-meshheading:2871530-Glutamates,
pubmed-meshheading:2871530-Glutamic Acid,
pubmed-meshheading:2871530-Hippocampus,
pubmed-meshheading:2871530-Locus Coeruleus,
pubmed-meshheading:2871530-Male,
pubmed-meshheading:2871530-Neural Pathways,
pubmed-meshheading:2871530-Norepinephrine,
pubmed-meshheading:2871530-Rats,
pubmed-meshheading:2871530-Synaptic Transmission
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pubmed:year |
1986
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pubmed:articleTitle |
Glutamate-induced activation of rat locus coeruleus increases CA1 pyramidal cell excitability.
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pubmed:publicationType |
Journal Article
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