| pubmed-article:2871125 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2871125 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2871125 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:2871125 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:2871125 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2871125 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:2871125 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:2871125 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:2871125 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:2871125 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2871125 | pubmed:dateCreated | 1986-6-6 | lld:pubmed |
| pubmed-article:2871125 | pubmed:abstractText | This study examines the potential role of transforming growth factor beta (TGF-beta) in the regulation of human T lymphocyte proliferation, and proposes that TGF-beta is an important autoregulatory lymphokine that limits T lymphocyte clonal expansion, and that TGF-beta production by T lymphocytes is important in T cell interactions with other cell types. TGF-beta was shown to inhibit IL-2-dependent T cell proliferation. The addition of picograms amounts of TGF-beta to cultures of IL-2-stimulated human T lymphocytes suppressed DNA synthesis by 60-80%. A potential mechanism of this inhibition was found. TGF-beta inhibited IL-2-induced upregulation of the IL-2 and transferrin receptors. Specific high-affinity receptors for TGF-beta were found both on resting and activated T cells. Cellular activation was shown to result in a five- to sixfold increase in the number of TGF-beta receptors on a per cell basis, without a change in the affinity of the receptor. Finally, the observations that activated T cells produce TGF-beta mRNA and that TGF-beta biologic activity is present in supernatants conditioned by activated T cells is strong evidence that T cells themselves are a source of TGF-beta. Resting T cells were found to have low to undetectable levels of TGF-beta mRNA, while PHA activation resulted in a rapid increase in TGF-beta mRNA levels (within 2 h). Both T4 and T8 lymphocytes were found to make mRNA for TGF-beta upon activation. Using both a soft agar assay and a competitive binding assay, TGF-beta biologic activity was found in supernatants conditioned by T cells; T cell activation resulted in a 10-50-fold increase in TGF-beta production. Thus, TGF-beta may be an important antigen-nonspecific regulator of human T cell proliferation, and important in T cell interaction with other cell types whose cellular functions are modulated by TGF-beta. | lld:pubmed |
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| pubmed-article:2871125 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2871125 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2871125 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2871125 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2871125 | pubmed:month | May | lld:pubmed |
| pubmed-article:2871125 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2871125 | pubmed:author | pubmed-author:FauciA SAS | lld:pubmed |
| pubmed-article:2871125 | pubmed:author | pubmed-author:DerynckRR | lld:pubmed |
| pubmed-article:2871125 | pubmed:author | pubmed-author:SpornM BMB | lld:pubmed |
| pubmed-article:2871125 | pubmed:author | pubmed-author:WakefieldL... | lld:pubmed |
| pubmed-article:2871125 | pubmed:author | pubmed-author:RobertsA BAB | lld:pubmed |
| pubmed-article:2871125 | pubmed:author | pubmed-author:KehrlJ HJH | lld:pubmed |
| pubmed-article:2871125 | pubmed:author | pubmed-author:Alvarez-MonMM | lld:pubmed |
| pubmed-article:2871125 | pubmed:author | pubmed-author:JakowlewSS | lld:pubmed |
| pubmed-article:2871125 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2871125 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2871125 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:2871125 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2871125 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2871125 | pubmed:pagination | 1037-50 | lld:pubmed |
| pubmed-article:2871125 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2871125 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2871125 | pubmed:articleTitle | Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. | lld:pubmed |
