Linked Life Data

2870926

Source:http://linkedlifedata.com/resource/pubmed/id/2870926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-5-28
pubmed:abstractText
Effects on the alpha-adrenoceptor binding in the kidneys of DOCA-salt rats were examined after a 6 week treatment of once-daily injections of prazosin, a selective alpha 1-adrenoceptor blocker; yohimbine, a selective antagonist for alpha 2-adrenoceptors; and prazosin plus yohimbine. alpha 1-Receptor binding was decreased by prazosin, while alpha 2-receptor binding was increased by simultaneous administration of prazosin + yohimbine. Equilibrium dissociation constants (KD) for [3H]prazosin and [3H]yohimbine were not significantly different (between groups). Since these drugs can prevent the development of hypertension in DOCA-salt rats, the present data strongly suggests that selective alteration of alpha-receptor-mediated physiological responses is unrelated to decreased or increased binding site densities. The mechanism of hypertension prevention may involve changes in the coupling of receptors to postreceptor events.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Altered renal alpha-adrenoceptor regulation in DOCA-salt rats: chronic effects of alpha 1- and alpha 2-receptor blockers.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't