| pubmed-article:2870496 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2870496 | lifeskim:mentions | umls-concept:C0008643 | lld:lifeskim |
| pubmed-article:2870496 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2870496 | lifeskim:mentions | umls-concept:C0008668 | lld:lifeskim |
| pubmed-article:2870496 | lifeskim:mentions | umls-concept:C0020375 | lld:lifeskim |
| pubmed-article:2870496 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:2870496 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:2870496 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:2870496 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:2870496 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:2870496 | pubmed:dateCreated | 1986-5-8 | lld:pubmed |
| pubmed-article:2870496 | pubmed:abstractText | A series of hybrids between primary human cells and a Chinese hamster somatic cell mutant (Mev-1), defective in expression of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase [(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating, EC 4.1.3.5], has been prepared that complements the mutant defect. A technique based on differential sensitivity of this enzyme activity to inhibition by magnesium ion is described that allows the discrimination of expression of human and hamster HMG-CoA synthase in these hybrids. The results indicate a structural gene defect in expression of HMG-CoA synthase activity in Mev-1 cells. Segregation of human chromosomes that do not possess the complementing marker have allowed the assignment of human HMG-CoA synthase activity to chromosome 5. This is the second demonstrably transcriptionally regulated enzyme of cholesterologenesis to be assigned to chromosome 5, the other being HMG-CoA reductase. | lld:pubmed |
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| pubmed-article:2870496 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2870496 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2870496 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2870496 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2870496 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2870496 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2870496 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2870496 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2870496 | pubmed:author | pubmed-author:JonesCC | lld:pubmed |
| pubmed-article:2870496 | pubmed:author | pubmed-author:SinenskyMM | lld:pubmed |
| pubmed-article:2870496 | pubmed:author | pubmed-author:LeonardSS | lld:pubmed |
| pubmed-article:2870496 | pubmed:author | pubmed-author:GeyerDD | lld:pubmed |
| pubmed-article:2870496 | pubmed:author | pubmed-author:ArbogastDD | lld:pubmed |
| pubmed-article:2870496 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2870496 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:2870496 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2870496 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2870496 | pubmed:pagination | 2187-9 | lld:pubmed |
| pubmed-article:2870496 | pubmed:dateRevised | 2011-11-4 | lld:pubmed |
| pubmed-article:2870496 | pubmed:meshHeading | pubmed-meshheading:2870496-... | lld:pubmed |
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| pubmed-article:2870496 | pubmed:meshHeading | pubmed-meshheading:2870496-... | lld:pubmed |
| pubmed-article:2870496 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:2870496 | pubmed:articleTitle | Localization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A synthase to human chromosome 5. | lld:pubmed |
| pubmed-article:2870496 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2870496 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2870496 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3157 | entrezgene:pubmed | pubmed-article:2870496 | lld:entrezgene |
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