Linked Life Data

2868919

Source:http://linkedlifedata.com/resource/pubmed/id/2868919

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-4-9
pubmed:abstractText
Interaction between the clinical, EEG-effects and phenazepam concentration in the blood was studied in 111 patients with neurotic disorders after intake of the test drug dose (2 mg) administered singly and on the 14th day of the treatment. It was established that EEG changes commonly induced by benzodiazepines supervene primarily within the interval of 1 to 3 h after a single intake which correlates with the maximal degree of the tranquilizing, somnolent and myorelaxant drug action. It was demonstrated that the clinical and EEG-effects occur before attainment of the maximal phenazepam concentration and then become less potent, with preservation of the high blood drug level. Intake of the test dose during the treatment course is characterized, as compared with the effect of a single intake, by less marked clinical action of the drug and the lack of significant changes on the EEG and in the blood phenazepam concentration.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0014-8318
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
66-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
[Correlation of the clinical pharmacological action of a single dose of fenazepam with the EEG dynamics and pharmacokinetics].
pubmed:publicationType
Journal Article, English Abstract