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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1986-3-7
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pubmed:abstractText |
The anxiolytic-sedative drugs thalidomide and supidimide inhibited spontaneous motor activity in rats. Both compounds inhibited the serotonin (5-HT) behavioural syndrome induced by tranylcypromine (TCP) plus L-tryptophan (TRP) or clorgyline plus the selective 5-HT uptake blocker, LM 5008 (4-[2-(3-indolyl)ethyl]piperidine) and delayed the behavioural effects of p-chloro-amphetamine, a releaser of 5-HT. The behavioural syndrome induced by the 5-HT agonist, 5-methoxy-N,N'-dimethyltryptamine (5-MeODMT) was unaffected by supidimide pretreatment. Thus supidimide does not possess 5-HT receptor antagonistic properties. This was further substantiated by the unaltered 5-HT-induced platelet aggregation in the presence of supidimide (10(-7)-10(-4) M). A decrease of 5-HT release into the synaptic cleft will lead to a diminished behavioural response to drugs that act presynaptically. Supidimide induced a greater increase in accumulation of brain 5-HT in TCP (5 mg/kg) plus TRP (100 mg/kg)-treated animals as compared to that in the corresponding controls. These data indicate that the behavioural and pharmacological actions of supidimide may be related to its inhibition of 5-HT release.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Anxiety Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines,
http://linkedlifedata.com/resource/pubmed/chemical/Clorgyline,
http://linkedlifedata.com/resource/pubmed/chemical/Methoxydimethyltryptamines,
http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Thalidomide,
http://linkedlifedata.com/resource/pubmed/chemical/Tranylcypromine,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan,
http://linkedlifedata.com/resource/pubmed/chemical/indalpine,
http://linkedlifedata.com/resource/pubmed/chemical/p-Chloroamphetamine,
http://linkedlifedata.com/resource/pubmed/chemical/supidimide
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-46
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2867921-Animals,
pubmed-meshheading:2867921-Anti-Anxiety Agents,
pubmed-meshheading:2867921-Brain,
pubmed-meshheading:2867921-Catecholamines,
pubmed-meshheading:2867921-Clorgyline,
pubmed-meshheading:2867921-Dose-Response Relationship, Drug,
pubmed-meshheading:2867921-Humans,
pubmed-meshheading:2867921-Male,
pubmed-meshheading:2867921-Methoxydimethyltryptamines,
pubmed-meshheading:2867921-Monoamine Oxidase,
pubmed-meshheading:2867921-Motor Activity,
pubmed-meshheading:2867921-Piperidines,
pubmed-meshheading:2867921-Platelet Aggregation,
pubmed-meshheading:2867921-Rats,
pubmed-meshheading:2867921-Rats, Inbred Strains,
pubmed-meshheading:2867921-Serotonin,
pubmed-meshheading:2867921-Serotonin Antagonists,
pubmed-meshheading:2867921-Thalidomide,
pubmed-meshheading:2867921-Tranylcypromine,
pubmed-meshheading:2867921-Tryptophan,
pubmed-meshheading:2867921-p-Chloroamphetamine
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pubmed:year |
1985
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pubmed:articleTitle |
Serotonergic involvement in pharmacological action of the anxiolytic-sedatives thalidomide and supidimide.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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