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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-2-24
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pubmed:abstractText |
The antivasopressor analog d(CH2)5Tyr(Me) arginine-vasopressin completely blocked the convulsive-like behavior and other severe motor disturbances which are normally observed following a second central arginine-vasopressin injection. This vasopressor antagonist appears to be selective for arginine-vasopressin-induced motor disturbances, in that the convulsive and motor effects of pentylenetetrazol and somatostatin were not altered significantly by pretreatment with the central antagonist. Results suggest that arginine-vasopressin-induced motor disturbances are mediated via central receptors. The classic antidiuretic (V2) type of arginine-vasopressin receptor does not appear to be involved, since the agonist 1-desamino-8-D-arginine-vasopressin did not elicit convulsive-like behavior or other severe motor disturbances 2 days following a first ('priming') injection of arginine-vasopressin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
362
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
40-6
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pubmed:dateRevised |
2008-8-16
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pubmed:meshHeading |
pubmed-meshheading:2867814-Animals,
pubmed-meshheading:2867814-Arginine Vasopressin,
pubmed-meshheading:2867814-Brain Diseases,
pubmed-meshheading:2867814-Deamino Arginine Vasopressin,
pubmed-meshheading:2867814-Drug Hypersensitivity,
pubmed-meshheading:2867814-Male,
pubmed-meshheading:2867814-Movement Disorders,
pubmed-meshheading:2867814-Pentylenetetrazole,
pubmed-meshheading:2867814-Rats,
pubmed-meshheading:2867814-Rats, Inbred Strains,
pubmed-meshheading:2867814-Somatostatin,
pubmed-meshheading:2867814-Vasoconstrictor Agents
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pubmed:year |
1986
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pubmed:articleTitle |
Prevention of arginine-vasopressin-induced motor disturbances by a potent vasopressor antagonist.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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