Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-2-13
pubmed:abstractText
Evidence from studies which utilise either opiate receptor agonists and antagonists strongly indicate a role for endorphinergic mechanisms in the control of feeding responses. Two means by which these compounds may exert an effect on feeding can be singled-out. Firstly, emerging evidence suggests that the process of achieving satiety (terminating a meal, or choice of a commodity) may be accelerated following treatments with opiate receptor antagonists. Secondly, the preference for highly palatable solutions (sweet solutions have received most attention) in two-bottle tests is blocked after injection of opiate receptor antagonists. This finding has been interpreted in terms of the abolition of the reward or incentive quality associated with the particularly attractive flavour. These two mechanisms of action may represent two aspects of a single, fundamental process. Following an introduction to rat urination model of in vivo kappa agonist activity, the consistent effect of several kappa agonists (including the highly selective U-50,488H) to stimulate food consumption is described. Recognising that members of the dynorphin group of endogenous opioid peptides are kappa receptor ligands, some with a high degree of selectivity, and the evidence the dynorphins and neo-endorphins produce hyperphagia in rats is particularly interesting. Such lines of evidence lead to the hypothesis that peptides of the dynorphin group may act endogenously to promote the expression of normal feeding behaviour.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dichloro-N-methyl-N-(2-(1-pyrrol..., http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, http://linkedlifedata.com/resource/pubmed/chemical/Benzodiazepines, http://linkedlifedata.com/resource/pubmed/chemical/Benzomorphans, http://linkedlifedata.com/resource/pubmed/chemical/Butorphanol, http://linkedlifedata.com/resource/pubmed/chemical/Cyclazocine, http://linkedlifedata.com/resource/pubmed/chemical/Dynorphins, http://linkedlifedata.com/resource/pubmed/chemical/Endorphins, http://linkedlifedata.com/resource/pubmed/chemical/Ethylketocyclazocine, http://linkedlifedata.com/resource/pubmed/chemical/Morphine, http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Phenazocine, http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa, http://linkedlifedata.com/resource/pubmed/chemical/SK&F 10047, http://linkedlifedata.com/resource/pubmed/chemical/bremazocine, http://linkedlifedata.com/resource/pubmed/chemical/ketazocine, http://linkedlifedata.com/resource/pubmed/chemical/tifluadom
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
889-901
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:2867562-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benz..., pubmed-meshheading:2867562-Analgesics, pubmed-meshheading:2867562-Animals, pubmed-meshheading:2867562-Benzodiazepines, pubmed-meshheading:2867562-Benzomorphans, pubmed-meshheading:2867562-Butorphanol, pubmed-meshheading:2867562-Choice Behavior, pubmed-meshheading:2867562-Cyclazocine, pubmed-meshheading:2867562-Diuresis, pubmed-meshheading:2867562-Drinking, pubmed-meshheading:2867562-Dynorphins, pubmed-meshheading:2867562-Eating, pubmed-meshheading:2867562-Endorphins, pubmed-meshheading:2867562-Ethylketocyclazocine, pubmed-meshheading:2867562-Humans, pubmed-meshheading:2867562-Morphine, pubmed-meshheading:2867562-Narcotic Antagonists, pubmed-meshheading:2867562-Phenazocine, pubmed-meshheading:2867562-Pyrrolidines, pubmed-meshheading:2867562-Receptors, Opioid, pubmed-meshheading:2867562-Receptors, Opioid, kappa, pubmed-meshheading:2867562-Satiety Response
pubmed:year
1985
pubmed:articleTitle
Endorphins and food intake: kappa opioid receptor agonists and hyperphagia.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't