|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1986-1-9
|
|
pubmed:abstractText |
An animal model of tardive dyskinesia was used for the evaluation of potential antidyskinetic properties of the neuropeptide L-Prolyl-L-Leucyl-glycinamide (PLG) and related drugs: cyclo[glycine-(1-amino-1-cyclopentane) carbonyl]--c(CPC-Gly) and cyclo[alanine-(1-amino-1-cyclopentane) carbonyl]--c(CPC-Ala). Dopaminergic supersensitivity was induced by repeated administration of the neuroleptic drug isofloxythepin. Isofloxythepin (5 mg/kg/day po) after the withdrawal increased Bmax of 3H-spiperone striatal binding sites, significantly decreased HVA level in the striatum and induced tolerance to the cataleptic effects challenged by perphenazine. PLG, c(CPC-Gly) and c(CPC-Ala) counteracted supersensitive responses of isofloxythepin. The use of c(CPC-Gly) and c(CPC-Ala) in the prevention of tardive dyskinesia is proposed.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0301-0244
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
37
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
311-5
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:2866500-Animals,
pubmed-meshheading:2866500-Corpus Striatum,
pubmed-meshheading:2866500-Dibenzothiepins,
pubmed-meshheading:2866500-Disease Models, Animal,
pubmed-meshheading:2866500-Drug Evaluation, Preclinical,
pubmed-meshheading:2866500-Drug Tolerance,
pubmed-meshheading:2866500-Dyskinesia, Drug-Induced,
pubmed-meshheading:2866500-Lisuride,
pubmed-meshheading:2866500-MSH Release-Inhibiting Hormone,
pubmed-meshheading:2866500-Male,
pubmed-meshheading:2866500-Neuropeptides,
pubmed-meshheading:2866500-Peptides, Cyclic,
pubmed-meshheading:2866500-Rats,
pubmed-meshheading:2866500-Rats, Inbred Strains,
pubmed-meshheading:2866500-Receptors, Dopamine
|
|
pubmed:articleTitle |
The use of striatal dopaminergic supersensitivity for the evaluation of drugs with possible antidyskinetic properties.
|
|
pubmed:publicationType |
Journal Article
|
