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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1986-1-22
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pubmed:abstractText |
Two major populations of perivascular axons containing immunoreactivity to neuropeptide Y (NPY) have been revealed in the main uterine artery of the guinea pig by immunohistochemical procedures which allow the simultaneous visualization of two antigens. One population contained immunoreactivity to dopamine-beta-hydroxylase (D beta H) and was presumably noradrenergic. The other main population of axons with NPY-like immunoreactivity (NPY-LI) did not have D beta H-like immunoreactivity (D beta H-LI) and was presumably non-noradrenergic. These non-noradrenergic axons also contained immunoreactivity to vasoactive intestinal polypeptide (VIP) and dynorphin (DYN). Indeed, nearly all axons with VIP-LI also contained NPY-LI and DYN-like immunoreactivity (DYN-LI). NPY constricted the uterine artery perfused in vitro, whilst VIP dilated uterine arteries preconstricted with noradrenaline or NPY. Thus, we have evidence for the coexistence of a vasoconstrictor peptide and a vasodilator peptide in the same non-noradrenergic perivascular axons, which also contain an opioid peptide, dynorphin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2866474-Animals,
pubmed-meshheading:2866474-Arteries,
pubmed-meshheading:2866474-Axons,
pubmed-meshheading:2866474-Dynorphins,
pubmed-meshheading:2866474-Female,
pubmed-meshheading:2866474-Guinea Pigs,
pubmed-meshheading:2866474-Histocytochemistry,
pubmed-meshheading:2866474-Immunochemistry,
pubmed-meshheading:2866474-Nerve Tissue Proteins,
pubmed-meshheading:2866474-Neuropeptide Y,
pubmed-meshheading:2866474-Tissue Distribution,
pubmed-meshheading:2866474-Uterus,
pubmed-meshheading:2866474-Vasoactive Intestinal Peptide
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pubmed:year |
1985
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pubmed:articleTitle |
Co-localization of neuropeptide Y, vasoactive intestinal polypeptide and dynorphin in non-noradrenergic axons of the guinea pig uterine artery.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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