Linked Life Data

2865354

Source:http://linkedlifedata.com/resource/pubmed/id/2865354

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-12-20
pubmed:abstractText
The effect of repeated s.c. administration of various neuroleptics (haloperidol, sulpiride and cis-flupentixol) on the in vivo release and metabolism of dopamine (DA) was studied in freely moving rats using trans striatal dialysis coupled to reverse-phase high-pressure liquid chromatography with electrochemical detection. Acute administration of neuroleptics dose-dependently but transiently stimulates DA release whereas lastingly stimulating DA metabolism. Administration of a second dose of neuroleptic, 4 to 12 hr after a priming dose, fails to stimulate DA release or stimulates it less effectively than in normal rats. A normal stimulatory response of DA release is reinstated when at least a 24-hr delay between the two doses is allowed. In contrast, the ability of the second neuroleptic dose to affect DA metabolism is unchanged. The results indicate that rapid tolerance takes place to neuroleptic-induced stimulation of DA release but not of DA metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
235
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
487-94
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Rapid tolerance to neuroleptic-induced stimulation of dopamine release in freely moving rats.
pubmed:publicationType
Journal Article