rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
19
|
pubmed:dateCreated |
1985-10-31
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pubmed:databankReference |
|
pubmed:abstractText |
The human Thy-1 gene has been isolated and sequenced and compared to the rat and mouse Thy-1 genes. All three genes are organized in the same way: one exon encoding the majority of the signal peptide, another encoding the transmembrane segment, and a third encoding the remainder of the protein. One major structural difference between the human and rodent Thy-1 glycoproteins is that the former contains two instead of three glycosylation sites. RNA blot analysis of a human T-cell line expressing the T3 complex showed an absence of Thy-1 mRNA, excluding the possibility that Thy-1 represents one of the component chains of T3. The structural gene for human Thy-1 was localized to the long arm of chromosome 11 by nucleic acid hybridization to genomic DNA isolated from somatic cell hybrids.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
6657-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2864690-Amino Acid Sequence,
pubmed-meshheading:2864690-Animals,
pubmed-meshheading:2864690-Antigens, Surface,
pubmed-meshheading:2864690-Antigens, Thy-1,
pubmed-meshheading:2864690-B-Lymphocytes,
pubmed-meshheading:2864690-Base Sequence,
pubmed-meshheading:2864690-Chromosome Mapping,
pubmed-meshheading:2864690-Chromosomes, Human, 6-12 and X,
pubmed-meshheading:2864690-DNA, Recombinant,
pubmed-meshheading:2864690-Genes,
pubmed-meshheading:2864690-Humans,
pubmed-meshheading:2864690-Mice,
pubmed-meshheading:2864690-Rats,
pubmed-meshheading:2864690-Recombinant Proteins,
pubmed-meshheading:2864690-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2864690-Species Specificity
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pubmed:year |
1985
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pubmed:articleTitle |
The human Thy-1 gene: structure and chromosomal location.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|