Linked Life Data

2864269

Source:http://linkedlifedata.com/resource/pubmed/id/2864269

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-11-8
pubmed:abstractText
The possible role of medullary somatostatin as a neurotransmitter involved in blood pressure regulation was examined. Blood pressure and heart rate were measured in pentobarbital anesthetized rats while pmol quantities of somatostatin-28 (SS28), SS28-(15-28) (somatostatin-14), SS28-(1-12) or SS28-(1-10) were injected into the caudal nucleus tractus solitarii (NTS). Injection of artificial cerebrospinal fluid (ACSF; 500 nl/10 s) alone was followed by a small (2 mmHg) statistically insignificant decrease in blood pressure. SS28, SS28-(15-28) or SS28-(1-12) induced an immediate and statistically significant decrease in blood pressure as compared to vehicle alone. SS28-(1-10) had no significant effect. SS28 was tested at three doses. The lowest dose of SS28 (2.5 pmol) induced an 8 mmHg drop in blood pressure, the medium dose (25 pmol), an 11 mmHg drop and the highest dose (250 pmol) a 16 mmHg drop. The other peptide fragments were tested only at the higher 250 pmol dose. SS28-(1-12) induced a significantly (P less than 0.01) less drop in blood pressure (10 mmHg) when compared to either SS28 or SS28-(15-28) (18-19 mmHg). The hypotensive and bradycardiac effects of SS28 were prevented by pretreatment with methylscopolamine (5 mg/kg i.p.) 10 min prior to SS28. The cardiovascular effects of intramedullary injected SS28 were also blocked with an ipsilateral NTS injection of yohimbine or tolazoline 10 min prior to SS28.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
425-30
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Blood pressure following microinjection of somatostatin related peptides into the rat nucleus tractus solitarii.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.