Linked Life Data

2863799

Source:http://linkedlifedata.com/resource/pubmed/id/2863799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-10-3
pubmed:abstractText
The intraocular pressure response to ACC-9447, a topical beta adrenergic antagonist, in six drug concentrations from 0.2% to 4.0%, was evaluated in 17 normal human subjects. ACC-9447 employs a new strategy for reducing systemic effects of ocular drugs by exploiting physiologic blood esterases to deactivate the drug rapidly after systemic absorbtion. Each patient received the test drug in one eye and placebo in the fellow eye. Intraocular pressure was measured nine times over the subsequent 24-hour period. The tests were repeated for six increasing concentrations over six weekend days. Although the eyes receiving ACC-9447 exhibited a significant 24-hour reduction in pressure from baseline, the effect was not different in placebo-treated eyes. Further studies are planned in ocular hypertensive patients using matched patient rather than fellow eye controls.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0161-6420
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
811-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
An ophthalmic beta antagonist with rapid systemic deactivation.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial