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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1985-10-23
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pubmed:abstractText |
The effect of xamoterol and (-)-isoprenaline have been compared for their activity at beta-adrenoceptor sites in a number of in vitro cardiac and smooth muscle preparations. Xamoterol produced weak positive chronotropic effects in guinea-pig, rat and cat atria (intrinsic activity less than 0.55, (-)-isoprenaline = 1). Positive inotropic effects were obtained in driven left atria of the cat but were absent in guinea-pig left atrial and right ventricular strip preparations. Agonistic effects were due to beta 1-adrenoceptor stimulation. Xamoterol was without beta-adrenoceptor-mediated inhibitory effects in guinea-pig ileal, tracheal and uterine preparations and in the rat vas deferens and oestrogen-primed uterus. Weak beta 2-adrenoceptor-mediated relaxation was obtained in progesterone-primed rat uteri. Xamoterol produced non-specific inhibitory effects in guinea-pig ileal and tracheal preparations. Xamoterol acted as a competitive antagonist at beta 1-(pA2 range = 7.4 to 7.8) and beta 2-adrenoceptors (pA2 range 5.2 to 6.2) and displaced [125I]-iodocyanopindolol from guinea-pig left atrial (pKD = 7.25) and uterine (pKD 5.24) membrane preparations. It is concluded that xamoterol displays a selective affinity for beta 1-adrenoceptors. Although its partial agonistic actions are more evident at beta 1-adrenoceptor sites, like prenalterol, xamoterol displays a degree of tissue rather than receptor-dependent selectivity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-13651579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-4156504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-4400509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6058154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6102602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6103722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6115058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6121816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6126381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6127403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6128041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6130188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6131123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6132344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6141007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6141243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6144558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6148117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6150092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6254391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-6319079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2862938-7236990
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-87
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2862938-Adrenergic beta-Agonists,
pubmed-meshheading:2862938-Adrenergic beta-Antagonists,
pubmed-meshheading:2862938-Animals,
pubmed-meshheading:2862938-Cats,
pubmed-meshheading:2862938-Female,
pubmed-meshheading:2862938-Fenoterol,
pubmed-meshheading:2862938-Guinea Pigs,
pubmed-meshheading:2862938-Heart,
pubmed-meshheading:2862938-Heart Rate,
pubmed-meshheading:2862938-Iodine Radioisotopes,
pubmed-meshheading:2862938-Iodocyanopindolol,
pubmed-meshheading:2862938-Isoproterenol,
pubmed-meshheading:2862938-Male,
pubmed-meshheading:2862938-Muscle, Smooth,
pubmed-meshheading:2862938-Norepinephrine,
pubmed-meshheading:2862938-Pindolol,
pubmed-meshheading:2862938-Propanolamines,
pubmed-meshheading:2862938-Rats,
pubmed-meshheading:2862938-Refractory Period, Electrophysiological,
pubmed-meshheading:2862938-Species Specificity,
pubmed-meshheading:2862938-Uterine Contraction,
pubmed-meshheading:2862938-Xamoterol
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pubmed:year |
1985
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pubmed:articleTitle |
The in vitro pharmacology of xamoterol (ICI 118,587).
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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