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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1985-8-26
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pubmed:abstractText |
The effects of four stereoisomers of beta-hydroxyglutamic acid (erythro-L-BHGA, threo-L-BHGA, erythro-D-BHGA and threo-D-BHGA) and glutamic acid (L-Glu and D-Glu) were compared on six identifiable giant neurons of Achatina fulica Férussac, namely, PON (periodically oscillating neuron), VIN (visceral intermittently firing neuron), d-RPLN (dorsal-right parietal large neuron), RAPN (right anterior pallial neuron), FAN (frequently autoactive neuron) and v-RCDN (ventral-right cerebral distinct neuron). On PON and VIN, erythro-L-BHGA was the most inhibitory (effective potency quotient (EPQ) of the substance: 1.0). Its minimum effective concentration (MEC) for both neurons was the same at 3 X 10(-5) M. The effect of threo-L-BHGA was weaker (EPQ in relation to the most effective substance: 0.3-0.1). Erythro- and threo-D-BHGAs were almost ineffective on PON (EPQ: less than 0.03) though they had some effects on VIN (EPQ: 0.1-0.03 for erythro-D-BHGA and 0.3-0.1 for threo-D-BHGA). On d-RPLN, erythro-L-BHGA was the most excitatory (MEC: 10(-4)M). Threo-L-BHGA and threo-D-BHGA also had some effects (EPQ: 0.1 and 0.3 respectively), while erythro-D-BHGA was ineffective. On RAPN, erythro- and threo-L-BHGAs were the most excitatory (MEC: 10(-4) M). Threo-D-BHGA was also excitatory (EPQ: 0.3), while erythro-D-BHGA was ineffective. Threo-L-BHGA was the most inhibitory on FAN and v-RCDN (MEC: 10(-4) M in FAN and 10(-5) M in v-RCDN).(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glutamates,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter,
http://linkedlifedata.com/resource/pubmed/chemical/hydroxyglutamic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2862044-Action Potentials,
pubmed-meshheading:2862044-Animals,
pubmed-meshheading:2862044-Glutamates,
pubmed-meshheading:2862044-Glutamic Acid,
pubmed-meshheading:2862044-Membrane Potentials,
pubmed-meshheading:2862044-Neurons,
pubmed-meshheading:2862044-Receptors, Glutamate,
pubmed-meshheading:2862044-Receptors, Neurotransmitter,
pubmed-meshheading:2862044-Snails,
pubmed-meshheading:2862044-Stereoisomerism,
pubmed-meshheading:2862044-Structure-Activity Relationship
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pubmed:year |
1985
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pubmed:articleTitle |
Effects of four stereoisomers of beta-hydroxyglutamic acid on identifiable giant neurons of an African giant snail (Achatina fulica Férussac).
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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