Linked Life Data

2860900

Source:http://linkedlifedata.com/resource/pubmed/id/2860900

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-7-8
pubmed:abstractText
Dipeptidyl peptidase IV can be demonstrated in 60% of T lymphocytes from human peripheral blood. As could be shown recently, this enzyme is irreversibly inhibited by N-Ala-Pro-O-(nitrobenzoyl-)hydroxylamine, a substrate analogous enzyme-activated inhibitor of X-Pro-specific peptidases. We found that this inhibitor was able to suppress the proliferation of human lymphocytes stimulated with mitogens or allogeneic cells. Furthermore, after stimulation with pokeweed mitogen the development of lymphocytes containing cytoplasmic immunoglobulins and thiol proteindisulfide oxidoreductase was reduced in the presence of this inhibitor. It is concluded that dipeptidyl peptidase IV is involved or might represent a limiting factor in the process of regulation of T lymphocyte proliferation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
K9-15
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The dipeptidyl peptidase IV, a membrane enzyme involved in the proliferation of T lymphocytes.
pubmed:publicationType
Journal Article, In Vitro